You’ve been feeling acute or frequent pain in the front of your knee(s), but you’re not a runner. So can you still have Runner’s Knee even if you do not run? Runner’s Knee, aka Patellofemoral Pain Syndrome (PFPS) or Chondromalacia Patella, is often the catchall diagnosis for broad-spectrum anterior (front) knee pain with activities that compress the kneecap (patellofemoral) joint.